Bronchogen (20mg) Peptide

Bronchogen (20mg) is a short-chain synthetic peptide classified among the well-known Khavinson bioregulatory peptides. Also referred to as AEDL, Bronchogen has been studied for its potential role in gene regulation, DNA interaction, and bronchial epithelial research models. Due to its concise amino acid structure and signaling characteristics, this peptide has gained interest in molecular biology, epigenetics, and respiratory-focused laboratory research.

At Core Peptide, Bronchogen (20mg) is supplied exclusively for laboratory and research use only, serving qualified researchers throughout the United States.

What Is Bronchogen?

Bronchogen is a tetrapeptide with the amino acid sequence Ala–Glu–Asp–Leu. Unlike longer peptides that primarily interact with cell surface receptors, Bronchogen belongs to a class of short signaling peptides proposed to penetrate cellular and nuclear membranes. Research suggests that peptides in this category may interact directly with DNA and influence gene expression.

According to peer-reviewed studies, Bronchogen may demonstrate tissue specificity for lung cells, potentially regulating genes such as:

• NKX2-1

• SCGB1A1

• SCGB3A2

• FOXA1

• FOXA2

These genes are widely studied in relation to bronchial epithelial cell differentiation, lung tissue structure, and inflammatory signaling pathways.
External reference: https://pubmed.ncbi.nlm.nih.gov

Chemical Makeup of Bronchogen (20mg)

• Molecular Formula: C₁₈H₃₀N₄O₉

• Molecular Weight: 446.45 g/mol

• Sequence: Ala–Glu–Asp–Leu

• Other Name: AEDL

Its compact molecular size allows Bronchogen (20mg) to be explored in studies related to DNA binding, epigenetic modulation, and intracellular signaling.

Bronchogen and DNA Interaction Research

One of the most compelling areas of Bronchogen research focuses on its interaction with DNA and deoxyribooligonucleotides. Studies indicate that Bronchogen may preferentially bind with DNA segments containing CNG sequences, which are common targets for cytosine DNA methylation in eukaryotic cells.

DNA methylation is a key epigenetic mechanism involved in regulating gene expression. By interacting with methylation-associated sites, Bronchogen may influence transcriptional activity without altering the DNA sequence itself. Researchers have suggested that this interaction could play a role in cell differentiation, inflammation modulation, and tissue remodeling pathways.

Additional studies observed that Bronchogen may increase DNA thermal stability, raising DNA melting temperature by approximately 3.1°C. This property suggests a stabilizing interaction with nitrogen bases through non-covalent forces such as hydrogen bonding.
Reference: https://doi.org/10.1007/s10517-011-1146-x

Bronchogen (20mg) and Cell Renewal Studies

Research involving bronchial epithelial cells suggests that Bronchogen may influence cell renewal and functional enhancement. Experimental findings indicate that the peptide binds to DNA—particularly at the guanine N7 site—without disrupting the double-helix structure. This targeted interaction suggests a regulatory role rather than a mutagenic one.

Researchers concluded that Bronchogen appeared to stimulate cell renewal processes and enhance functional activity in bronchial epithelial research models. These findings have generated interest in exploring Bronchogen as a tool in cellular aging, differentiation, and regenerative biology research.

Authoritative source: https://www.ncbi.nlm.nih.gov

Bronchogen and Inflammatory Response Models

Several murine studies have explored Bronchogen’s role in bronchial epithelium inflammation models, particularly those induced by prolonged nitrogen dioxide (NO₂) exposure. This model is commonly used to simulate chronic epithelial damage and inflammatory stress.

In these studies, Bronchogen was associated with:

• Reduced neutrophilic inflammation

• Normalization of pro-inflammatory cytokine profiles

• Increased secretory immunoglobulin A (IgA) levels

• Improved surfactant protein B expression

These outcomes suggest that Bronchogen may influence local immune signaling and epithelial barrier integrity within controlled laboratory environments.
External research source: https://doi.org/10.3390/molecules26227053

Bronchogen and Tissue Remodeling Research

Tissue remodeling is a key feature of chronic epithelial stress. Studies investigating Bronchogen (20mg) in long-term NO₂ exposure models showed potential attenuation of bronchial and lung tissue remodeling markers, including:

• Goblet cell hyperplasia

• Squamous metaplasia

• Lymphocytic infiltration

• Emphysematous changes

Researchers also observed potential restoration of ciliated epithelial cells, suggesting a normalization of epithelial structure. These findings highlight Bronchogen’s relevance in structural and functional tissue research models involving the respiratory system.

Why Choose Bronchogen (20mg) from Core Peptide?

At CorePeptide.us, we prioritize:

• Research-grade peptide purity

• Transparent product specifications

• USA-based fulfillment

• Strict research-only compliance

Our Bronchogen (20mg) peptide is intended for qualified laboratory professionals exploring gene expression, cellular signaling, and tissue-specific peptide research.